Safety Facts and Side Effects About Monosodium Glutamate

    Monosodium Glutamate, CAS# 142-47-2, is a sodium salt of glutamic acid manufactured through fermentation, available as white Powder. Monosodium Glutamate is widely used as flavourings. It is widely accepted as safe food additive in many countries with E number E621.
    Is there some safety and/or health risk about Monosodium Glutamate that consumers need to know? Let's check out some basic facts about this ingredient.
    GRAS Exemptions: Yes

    Generally recognized as safe(GRAS) is a FDA designation that a specific substance or ingredient is generally considered safe by experts, and so is exempted from the usual Federal Food, Drug, and Cosmetic Act (FFDCA) food additive tolerance requirements. Monosodium Glutamate is perfectly safe for using as food additives.
    Suggested Dosage

    As Monosodium Glutamate is widely known as safe, there is no limit on dosage of intake. However, we still recommend consumers to consult professionals before using large quantity of Monosodium Glutamate for long period.
    Special Groups Precaution

    Special groups refer to newborns, children, pregnant and any other applicable vulnerable groups.
    There is no evidence that Monosodium Glutamate could have any negative effects on these vulnerable groups. It should be safe to use Monosodium Glutamate in food for newborns and pregnant. However, we still recommend consumers to consult professionals before using large quantity of Monosodium Glutamate for long period in food for newborns or pregnant.
    General Side Effects

    Using of Monosodium Glutamate in large quantity (more than 2.2g/day) could cause significant obesity.
    Reported Health Issues

    1. New Link Between Monosodium Glutamate (MSG) and Fatty Liver
    Reference: https://www.liversupport.com/wordpress/2014/07/new-link-between-msg-and-fatty-liver/
    Related Research

    1. The safety evaluation of monosodium glutamate. [J Nutr. 2000 Apr]
    Author: Walker R, Lupien JR.

    2. [The effect of probiotic therapy on development of experimental obesity in rats caused by monosodium glutamate]. [Fiziol Zh. 2014]
    Author: Savcheniuk OA, Virchenko OV, Falalieieva TM, Beregova TV, Babenko LP, Lazarenko LM, Spivak MIa.

    3. Pathological Changes in Hepatocytes of Mice with Obesity-induced Type 2 Diabetes by Monosodium Glutamate. [Yakugaku Zasshi. 2014]
    Author: Nakadate K, Motojima K, Kamata S, Yoshida T, Hikita M, Wakamatsu H.

    4. Biochemical Alterations during the Obese-Aging Process in Female and Male Monosodium Glutamate (MSG)-Treated Mice. [Int J Mol Sci. 2014 Jun 27]
    Author: Hernández-Bautista RJ, Alarcón-Aguilar FJ, Del C Escobar-Villanueva M, Almanza-Pérez JC, Merino-Aguilar H, Fainstein MK, López-Diazguerrero NE.

    5. The sensitivity of male rat reproductive organs to monosodium glutamate. [Acta Med Acad. 2014]
    Author: Iamsaard S, Sukhorum W, Samrid R, Yimdee J, Kanla P, Chaisiwamongkol K, Hipkaeo W, Fongmoon D, Kondo H.


Source:https://www.foodchemadditives.com/side_effects_info/625